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Principal Investigators
Dr. Nick Daneman
Dr. Rob Fowler

Thanks to all Participating Centers and collaborators for engaging in this research program!

Thanks to the CCCTG for endorsing this research project.

BACKGROUND & RATIONALE


ANTIBIOTIC OVERUSE IS A GLOBAL HEALTH THREAT

The World Health Organization, U.S. Centers for Disease Control, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Canadian Federal Health Minister have all declared antimicrobial resistance a global threat to health, based on rapidly increasing resistance rates and declining new antimicrobial drug development.
 

PROLONGED TREATMENT DURATIONS ARE THE GREATEST CONTRIBUTOR TO ANTIBIOTIC OVERUSE

Up to 30-50% of antibiotic use is inappropriate, and excessive durations of antibiotic treatment are the greatest contributor to inappropriate use. Unnecessarily prolonged antibiotic use is contributing to preventable complications, C. difficile infections, and antimicrobial resistance among patients, and preventable costs for the healthcare system.  Large numbers of studies have confirmed that shorter duration treatment (≤ 7 days) is as effective as longer duration treatment for a range of infections, including lung, skin and soft tissue, intra-abdominal, and urinary tract infections.

EVIDENCE IS LACKING FOR THE OPTIMAL TREATMENT DURATION FOR BLOODSTREAM INFECTIONS

Bloodstream infections are among the most common and serious infections in critically ill patients, affecting 50,000 Canadians per year, and more than 600,000 patients per year in North America, and 1,200,000 per year in Europe.  Yet, the optimal duration of treatment for these patients has not been studied.