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Implementing knowledge gained from BALANCE will not require new equipment, technology or advanced training of personnel. Instead, implementing shorter course treatment, if proven non-inferior, would be a simple intervention that could be widely implemented with cost-savings rather than cost increases. The result would be rapid large-scale reductions in antibiotic days of treatment across ICUs in Canada and across the globe.

Reductions in C. difficile infections, and antibiotic resistant organisms would then follow.  If shorter course treatment is sufficient for critically ill patients with bloodstream infections, then it might also be sufficient for less ill populations with bloodstream infections.  Therefore, the BALANCE trial findings could lead to very broad global reductions in antimicrobial use and pressure.

PROCALCITONIN-SUB-STUDY Download 2016-07-19 3:27:04 PM
MICROBIOME-SUB-STUDY Download 2016-07-19 3:26:21 PM