Recent Documents
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Principal Investigators
Dr. Nick Daneman
Dr. Rob Fowler

Steering Committee
Dr. Deborah Cook
Dr. Rick Hall
Dr. John Muscedere
Dr. Ruxandra Pinto
Dr. Steven Reynolds
Dr. Ben Rogers
Dr. Yahya Shehabi
Dr. Shay McGuinness
Dr. Rachael Parke
Dr. Yaseen Arabi

Thanks to all Participating Centers and collaborators for engaging in this research program!

Thanks to the CCCTG for endorsing this research project.


Implementing knowledge gained from BALANCE will not require new equipment, technology or advanced training of personnel. Instead, implementing shorter course treatment, if proven non-inferior, would be a simple intervention that could be widely implemented with cost-savings rather than cost increases. The result would be rapid large-scale reductions in antibiotic days of treatment across ICUs in Canada and across the globe.

Reductions in C. difficile infections, and antibiotic resistant organisms would then follow.  If shorter course treatment is sufficient for critically ill patients with bloodstream infections, then it might also be sufficient for less ill populations with bloodstream infections.  Therefore, the BALANCE trial findings could lead to very broad global reductions in antimicrobial use and pressure.

BALANCE-UTI-SUB_STUDY Download 2021-03-25 9:48:10 AM
MICROBIOME-SUB-STUDY Download 2016-07-19 3:26:21 PM